Welcome to the Runs of Homozygosity Analysis Tutorial!ΒΆ
Updated: July 22, 2011
Level: Intermediate
Modules: HelixTree, WGA Module, Regression Module
Contents: Jump to Table of Contents
Dr. Todd Lencz, Associate Director of Research at The Zucker Hillside Hospital, working in collaboration with Dr. Christophe Lambert of Golden Helix, has developed a novel analytic approach that first identifies patterned clusters of SNPs demonstrating extended homozygosity (runs of homozygosity or “ROHs”) and then employs both genome-wide and regionally-specific statistical tests for association to disease. This approach can identify chromosomal segments that may harbor rare, penetrant recessive loci.
Using a simulated dataset, this tutorial will lead you step-by-step through the workflow for finding runs of homozygosity outlined in Dr. Lencz’s paper.
Note
This tutorial will not cover the data importing and quality control procedures Dr. Lencz employed in his study, most of which can be done with SNP & Variation Suite 7. To learn more about these procedures, please refer to the manual.
Requirements
To complete this tutorial you will need the following:
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We hope you enjoy the experience and look forward to your feedback.
Table of Contents:
